鄭智仁

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鄭智仁（英語：Cheng Chi Yan, Brian）中醫博士，英屬香港出生（1986年10月16日）。現為卓健醫療服務有限公司醫務總監（中醫服務）[1][2]，亦是香港中醫藥管理委員會註冊中醫(全科)，香港理工大學客席講師，英國生物醫學研究院士，英國皇家公共衛生學會院士，英國皇家醫學會資深準會士及香港免疫學會會員[3]。

個人簡介

鄭智仁擁有香港浸會大學中醫學學士學位（BChiMed），生物醫學理學士（一級榮譽）學位（BSc），以及中醫學哲學博士學位（Ph.D.）。他曾任職於香港浸會大學「癌症及炎症研究中心」，致力於研究傳統中藥之現代抗炎、抗癌藥理及中藥的質量控制。鄭博士擁有多年大專院校及中醫培訓機構之教學經驗，他曾於香港理工大學專上學院及東華學院護士學校擔任客席講師，教授中醫藥及護理相關課程，並參與健康科學學士之課程設計:

  • CC1006 中國醫學基礎知識 Foundation of Chinese Medicine
  • CCN1012 中醫學基礎知識 Foundation of Traditional Chinese Medicine [4]
  • CCN2233 Human Biology 1 [5]
  • CCN3132 中醫治療基礎 Fundamentals of Chinese Medicinal Therapy [6]

鄭智仁亦曾於國際中醫中藥總會擔任客席講師，教授香港中醫藥管理委員會認可之註冊中醫專業進修課程。除教研經驗外，鄭博士一直在各中醫診所擔任臨床及行政職務[7][8]。

研究論文

鄭智仁博士的研究涉及風濕病學、腫瘤學、中藥標準化以及中藥飲片質量控制等領域，並曾於國際醫學期刊發表了超過40份的研究論文及學術會議摘要[9]。

期刊論文

1. Li MZ, Zhang Y, Zou HY, Wang YL, Cheng BCY, et al. Xiaoshuan enteric-coated capsule alleviates cognitive impairment by enhancing hippocampal glucose metabolism, hemodynamics and neuroplasticity of rat with chronic cerebral hypoperfusion. Sci Rep. 2018;8(1):7449.[10]

2. Guo H, Zhang Y, Cheng BCY, et al. Comparison of the chemical profiles and inflammatory mediator-inhibitory effects of three Siegesbeckia herbs used as Herba Siegesbeckiae (Xixiancao). BMC Complement Altern Med. 2018;18(1):141.[11]

3. Li MZ, Zhang Y, Zou HY, Ouyang JY, Zhan Y, Yang L, Cheng BCY, et al. Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis. Biomed Pharmacother. 2018;103:989-1001.[12]

4. Li M, Ouyang J, Zhang Y, Cheng BCY, et al. Effects of total saponins from Trillium tschonoskii rhizome on grey and white matter injury evaluated by quantitative multiparametric MRI in a rat model of ischemic stroke. J Ethnopharmacol. 2018; 215:199-209.[13]

5. Tse AK, Chen YJ, Fu XQ, Su T, Li T, Guo H, Zhu PL, Kwan HY, Cheng BCY, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017;11:562-576.[14]

6. Cheng BCY, et al. The genus Rosa and arthritis: Overview on pharmacological perspectives. Pharmacol Res. 2016;114:219-234.[15]

7. Du J, Cheng BCY (co-first author), et al. In vitro assays suggest Shenqi Fuzheng Injection has the potential to alter melanoma immune microenvironment. J Ethnopharmacol. 2016;24;194:15-19.[16]

8. Su T, Zhang WW, Zhang YM, Cheng BCY, et al. Standardization of the manufacturing procedure for Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine. J Ethnopharmacol. 2016;193:663-669.[17]

9. Cheng BCY, et al. A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats. Sci Rep. 2016;6:20042.[18]

10. Cao HH, Chu JH, Kwan HY, Su T, Yu H, Cheng BCY, et al. Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. Sci Rep. 2016;6:21731.[19]

11. Su T, Cheng BCY, et al. Comparison of the toxicities, activities and chemical profiles of raw and processed Xanthii Fructus. BMC Complement Altern Med. 2016;16(1):24.[20]

12. Shu X, Jiang XW, Cheng BCY et al. Ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry analysis of the impact of processing on toxic components of Kansui Radix. BMC Complement Altern Med. 2016;16(1):73.[21]

13. Ma XQ, Li SM, Chan CL, Su T, Cheng BCY, et al. Influence of sulfur fumigation on volatile oil constituents of Codonopsis radix (dangshen) by GC-MS method. AJTCAM. 2016; 13(3):197. [22]

14. Cheng BCY, et al. A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos inhibits the production of inflammatory mediators and the IRAK-1/TAK1 and TBK1/IRF3 pathways in RAW 264.7 and THP-1 cells. J Ethnopharmacol. 2015;174:195-9. [23]

15. Ye Y, Chao XJ, Wu JF, Cheng BCY, et al. ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells. Oncol Rep. 2015;34(3):1543-8.[24]

16. Cao HH, Cheng BCY, et al. Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer. 2015;14:103.[25]

17. Cheng BCY, et al. A herbal formula consisting of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. J Ethnopharmacol. 2014;153(3):922-7.[26]

18. Fu XQ, et al., Cheng BCY, Sun XG, Yu ZL. Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II. Exp Dermatol. 2014;23(11):855-7.[27]

19. Su T, et al., Cheng BCY, Leung AK, Chan CL, Li WD, Cao H, Fong WF, Yu ZL. Comparisons of the chemical profiles, cytotoxicities and anti-inflammatory effects of raw and rice wine-processed Herba Siegesbeckiae. J Ethnopharmacol. 2014;156:365-9.[28]

20. Cao HH, et al., Cheng BCY, Su T, Fong WF, Yu ZL. Quercetin Exerts Anti-melanoma Activities and Inhibits STAT3 Signaling. Biochem Pharmacol. 2014;87(3):424-34.[29]

21. Tse AK, Cao HH, Cheng BCY, et al. Indomethacin Sensitizes TRAIL-Resistant Melanoma cells to TRAIL-induced Apoptosis through ROS-mediated Up-regulation of Death Receptor 5 and Down-regulation of Survivin. J Invest Dermatol. 2014;134(5):1397-407.[30]

22. Tse AK, Chow KY, Cao HH, Cheng BCY, et al. The herbal compound Cryptotanshinone restores sensitivity in cancer cells that are resistant to the tumor necrosis factor-related apoptosis-inducing ligand. J Biol Chem . 2013;288(41):29923-33.[31]

23. Kwan HY, Hu YM, Chan CL, Cao HH, Cheng BCY, et al. Lipidomics identification of metabolic biomarkers in chemically induced hypertriglyceridemic mice. J Proteome Res. 2013;12(3):1387-1398. [32]

學術會議摘要

1. Cheng BCY, et al. A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos exerts anti-arthritic effects and inhibits IRAK1/TAK1/NF-κB, IRAK1/TAK1/AP-1 and TBK1/IRF3 signalling pathways. Annual Scientific Meeting of the Hong Kong Society for Immunology 2015. Aug. 5, 2015. Hong Kong.

2. Cheng BCY, et al. Anti-arthritic effects of a herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos in rats with collagen-induced arthritis. 11th International Postgraduate Symposium on Chinese Medicine. Aug. 15, 2015. Hong Kong.

3. Cheng BCY, et al. Anti-Arthritic Effect of a Herbal Diet Formula Comprising Fruits of Rosa Multiflora and Flowers of Lonicera Japonica. 17th International Conference on Food and Nutrition Technology. Jun. 28-29, 2015. London.

4. Cheng BCY, et al. In vivo and in vitro anti-arthritic efficacy of a herbal formula consisting of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos. The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine. Jul. 22-24, 2015. Singapore.

5. Cheng BCY, et al. Investigation of the anti-inflammatory efficacy and mechanism of action of a herbal formula consisting of Rosa Multiflorae Fructus and Lonicerae Japonicae Flos. The 10th international postgraduate symposium on Chinese medicine. Aug. 15, 2014. Hong Kong.

6. Yu ZL, Su T, Guo H, Cheng BCY, et al. Processing reduced the toxicity and enhanced the efficacy of Xanthii Fructus. 3rd International Conference and Exhibition on Pharmacognosy, Phytochemistry and Natural products. 26 Oct, 2015. Hyderabad, India.

7. Guo H, Li T, Fu XQ, Su T, Cheng BCY, et al. High performance liquid chromatographic fingerprint and quantitative analysis for quality control of Pat Chun rice vinegar. 2015 11th International Postgraduate Symposium on Chinese Medicine. Aug. 15, 2015. Hong Kong.

8. Su T, Cheng BCY, et al. Stir-baking can reduce the cytotoxicity and enhance the efficacy of raw Xanthii Fructus. 2015 11th International Postgraduate Symposium on Chinese Medicine. Aug. 15, 2015. Hong Kong.

9. Fu XQ, Li T, Su T, Guo H, Cheng BCY, et al. Atractylenolide II Inhibits Invasion and Migration of Melanoma Cells by Downregulation of TLR4/STAT3 Signaling Pathway. 015 11th International Postgraduate Symposium on Chinese Medicine. Aug. 15, 2015. Hong Kong.

10. 蘇桃、鄭智仁等. 生半夏與薑半夏對大鼠毒性的對比研究. 第二次有毒中藥研究及其合理應用學術研討會. 2015年5月. 深圳.

11. 蘇桃、鄭智仁等.蒼耳子炮製減毒、增效的物質基礎探討. 第二次有毒中藥研究及其合理應用學術研討會. 2015年5月. 深圳.

12. 符秀瓊、蘇桃、李婷、鄭智仁等. 白朮內酯抗黑色素瘤作用的分子機制研究. 2015全國中藥及天然藥物資源的科學利用與可持續發展交流研討會. 2015年4月. 中國. 桂林市.

13. 曹惠慧、符秀瓊、蘇桃、李婷、鄭智仁等. 槲皮素抑制STAT3及c-Met信號通路且有抗黑色素瘤作用. 2015全國中藥及天然藥物資源的科學利用與可持續發展交流研討會. 2015年4月. 中國. 桂林市.

14. 蘇桃、符秀瓊、李婷、鄭智仁等.半夏醇提物誘導肝癌細胞凋亡並抑制 PI3K/AKT/mTOR通路. 2015全國中藥及天然藥物資源的科學利用與可持續發展交流研討會. 2015年4月. 中國. 桂林市.

15. 蘇桃、郭輝、李婷、符秀瓊、鄭智仁等. 炒制使蒼耳子降低了毒性、增強了活性、改變了化學成分. 2015全國中藥及天然藥物資源的科學利用與可持續發展交流研討會. 2015年4月. 中國. 桂林市.

16. 李婷、符秀瓊、蘇桃、鄭智仁等. 芹菜素抑制STAT3信號傳導並有抗黑色素瘤作用. 2015全國中藥及天然藥物資源的科學利用與可持續發展交流研討會. 2015年4月. 中國. 桂林市.

17. Chao XJ, Fu XQ, Cao HH, Su T, Cheng BCY, et al. Atractylenolide II exerts antimelanoma effects and inhibits the ERK/GSK-3β/c-Jun pathway. 2nd Annual International Conference on Advances in Cancer Medical Research. Dec., 2014, Singapore.

18. Su T, Cao HH, Fu XQ, Cheng BCY, et al. An ethanolic extract of Pinelliae Rhizoma inhibits proliferation and induces apoptosis through suppressing PI3K/AKT/mTOR/S6K1 signaling and ROS-mediated MAPKs activation in liver cancer cells. 2nd Annual International Conference on Advances in Cancer Medical Research. Dec., 2014, Singapore.

著作

經穴激活系統療法[33]


參考資料

  1. ↑ 卓健總監倡中醫院設專科制度
  2. ↑ 【專訪】中醫院顧問報告將出爐 卓健總監倡中醫院設專科制度,
  3. ↑ Brian Chi Yan Cheng 鄭智仁中醫
  4. ↑ CCN1012 中醫學基礎知識
  5. ↑ CCN2233 Human Biology 1
  6. ↑ CCN3132 Fundamentals of Chinese Medicinal Therapy
  7. ↑ 卓健總監倡中醫院設專科制度,
  8. ↑ 鄭智仁中醫 CHENG, CHI YAN| 鄭智仁中醫診所 電話 地址
  9. ↑ Brian Chi Yan Cheng PhD, BSc , BChiMed, FIBMS, FRSPH | Quality HealthCare Medical Services, Hong Kong | QHMS | Medical Affair & Chinese Medicine
  10. ↑ Xiaoshuan enteric-coated capsule alleviates cognitive impairment by enhancing hippocampal glucose metabolism, hemodynamics and neuroplasticity of rat with chronic cerebral hypoperfusion
  11. ↑ Comparison of the chemical profiles and inflammatory mediator-inhibitory effects of three Siegesbeckia herbs used as Herba Siegesbeckiae (Xixiancao)
  12. ↑ Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis
  13. ↑ Effects of total saponins from Trillium tschonoskii rhizome on grey and white matter injury evaluated by quantitative multiparametric MRI in a rat model of ischemic stroke
  14. ↑ Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition
  15. ↑ The genus Rosa and arthritis: Overview on pharmacological perspectives
  16. ↑ In vitro assays suggest Shenqi Fuzheng Injection has the potential to alter melanoma immune microenvironment
  17. ↑ Standardization of the manufacturing procedure for Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine
  18. ↑ A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats
  19. ↑ Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma
  20. ↑ Comparison of the toxicities, activities and chemical profiles of raw and processed Xanthii Fructus
  21. ↑ Ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry analysis of the impact of processing on toxic components of Kansui Radix
  22. ↑ Influence of sulfur fumigation on volatile oil constituents of Codonopsis radix (dangshen) by GC-MS method
  23. ↑ A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos inhibits the production of inflammatory mediators and the IRAK-1/TAK1 and TBK1/IRF3 pathways in RAW 264.7 and THP-1 cells
  24. ↑ ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells
  25. ↑ Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion
  26. ↑ A herbal formula consisting of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages
  27. ↑ Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II
  28. ↑ Comparisons of the chemical profiles, cytotoxicities and anti-inflammatory effects of raw and rice wine-processed Herba Siegesbeckiae
  29. ↑ Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
  30. ↑ Indomethacin Sensitizes TRAIL-Resistant Melanoma Cells to TRAIL-Induced Apoptosis through ROS-Mediated Upregulation of Death Receptor 5 and Downregulation of Survivin
  31. ↑ The Herbal Compound Cryptotanshinone Restores Sensitivity in Cancer Cells That Are Resistant to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand
  32. ↑ Lipidomics Identification of Metabolic Biomarkers in Chemically Induced Hypertriglyceridemic Mice
  33. ↑ 經穴激活系統療法 - 香港書城網上書店 Hong Kong Book City.
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